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NutrInsight • Slow-release carbohydrates: Growing evidence on metabolic responses and public health interest

Some clinical studies that were conducted in healthy subjects failed to show statistically significant differences
between glycemic responses, despite significant differences between rates of appearance of exogenous
glucose [Eelderink et al., 2012; Vinoy et al., 2013]. However, the results from these studies should be considered
with caution due to some potential methodological limitations, such as the sample size used in Eelderink et
al., 2012 (which was calculated to detect a statistical difference in RaE and not in glycemia) and the overly long
blood sampling intervals (every 30 min) used in Vinoy et al., 2013. Moreover, the use of a modified SDS method
to characterize cereal products in Eelderink et al., 2012 limits its comparison with other studies. Vinoy et al.,
2013 reported a second clinical trial in which the glycemic response measurements were replicated under the
same conditions (same test products and similar population tested), but with a more frequent blood sample
collection. The significantly lower glycemic response after consumption of the breakfast including the high
SDS cereal product was confirmed under these experimental conditions. This supports the hypothesis that the
glycemic peak have been missed due to sampling the blood every 30 min [Vinoy et al., 2013].
It can be concluded that the slow appearance of exogenous glucose in plasma induced by a high SDS content
in starchy foods is able to reduce the glycemic response in healthy subjects in most cases.

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