Page 22 - NUTRINSIGHT-5-HD

NutrInsight • Slow-release carbohydrates: Growing evidence on metabolic responses and public health interest

During the 7 to 8 years of follow-up, these non-diabetic subjects did not develop type 2 diabetes at the same
frequency: none of the subjects from group I developed the disease, whereas 53 out of 835 subjects (6.4%)
from Group IV did (see Figure 16).

Incidence (%) of Diabetes after 8 years 6.4%
7 (53/835)
6

5

4 3.2%
(10/313)

3

2
0.9%
(1/111)

1 0%
(0/23)

0

Group Group Group Group
I II III IV

Figure 16: Incidence of diabetes after 7-8 years based on the time (30, 60, 120 min, or never) that the plasma glucose
concentration during the oral glucose tolerance test (OGTT) declined below the fasting plasma glucose (FPG) concentration.
The incidence (%) is shown at the bar for each of the four groups. The number of subjects converted to diabetes and the total
number of subjects in each group are shown in parentheses below the incidence.
Source: Abdul-Ghani et al., 2006b

This study was the first to demonstrate that subjects with normal glycemic control can be stratified for risk
of progression to type 2 diabetes based on the glycemic profile after an OGTT. More broadly, the glycemic
control, even in non-diseased subjects, is an important aspect of type 2 diabetes prevention.

22